FOXP3 [86D]

FOXP3 [86D] is a mouse monoclonal antibody that is intended for laboratory use in the qualitative identification of FOXP3 protein by immunohistochemistry (IHC) in formalin-fixed paraffin-embedded (FFPE) human tissues. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient’s clinical history and other diagnostic tests by a qualified pathologist.

FOXP3 is a forkhead transcription factor family member involved in T-cell regulation, activation and differentiation. FOXP3 has been shown to be a master control gene for the development and function of CD4+/CD25+ regulatory T-cells. In IHC, FOXP3 has been shown to be a specific marker for adult T-cell leukemia/lymphoma. In melanoma and in breast and lung cancers, high numbers of circulating regulatory T cells have been associated with disease progression. Conversely, the infiltration of FOXP3+ regulatory T cells into invasive tumors has also been reported to be associated with survival in a variety of cancers. In colon cancers, a high frequency of FOXP3+ infiltrates has shown to be a positive indicator. Patients with high FOXP3 expression in Crohn’s disease have shown a better response to infliximab therapy. In allography recipients, FOXP3 cell levels may also be useful in improving post-transplant management.

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